TLR7/TLR8 activation and susceptibility genes synergize to breach gut barrier in a mouse model of lupus
BackgroundMounting evidence suggests that increased gut permeability, or leaky gut, and the resulting translocation of pathobionts or their metabolites contributes to the pathogenesis of Systemic Lupus Erythematosus.However, the mechanisms underlying the induction of gut leakage remain unclear.In this study, we examined the effect of a treatment wi